Transcranial Magnetic Stimulation as a Treatment for Postpartum Obsessive Compulsive Disorder
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age18-45
SponsorButler Hospital
About this trial
The goal of this clinical trial is to learn if accelerated transcranial magnetic stimulation (TMS) is a feasible treatment for obsessive compulsive disorder that worsens or starts within 12 months of childbirth. The main questions it aims to answer are:
Is TMS a tolerable and acceptable treatment for postpartum women with OCD?
Does TMS improve OCD symptoms in postpartum women?
Does TMS change connectivity between areas of the brain involved in OCD?
Participants will:
1. Receive 50 sessions of a type of TMS called continuous theta burst stimulation (cTBS) over the course of two weeks. 2. Complete clinical assessments before and after TMS, as well as at 1 and 3 months post-treatment 3. Undergo functional magnetic resonance imaging (fMRI) of the brain before and after TMS
Eligibility criteria
Qualifiers
Age 18-45
Diagnosis of OCD defined by DSM-V criteria with problematic symptoms in the 12 months following childbirth
YBOCS ≥16
Either currently taking OCD medications at a stable dose for 8 weeks or unmedicated
Disqualifiers
Past history of a primary psychotic or bipolar disorder
Current acute suicidality or significantly elevated risk of suicide as determined by the investigators
Personal history of moderate traumatic brain injury, epilepsy, or other clinically significant neurological illness except tic disorders
A history of pre-eclampsia during the most recent pregnancy if the patient is less than 8 weeks postpartum
Trial design
Treatments tested in this trial
- Accelerated Continuous Theta Burst Stimulation (cTBS)
Treatment groups
15 Participants
are divided into 1 treatment groupLocations
Sponsors and collaborators
Source ClinicalTrials.gov