Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-85
SponsorOregon Health and Science University
About this trial
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.
Eligibility criteria
Qualifiers
probable or possible PSP by the revised MDS PSP Criteria (Hoglinger 2017)
age 40-85 at time of screening
ability to understand and cooperate with simple instructions in English
ability to read at 6th grade reading level in English
Disqualifiers
other significant neurological or vestibular disorders
presence of electrically, magnetically or mechanically activated implants or history of injurious metal exposure in eyes, head, or body
Trial design
Treatments tested in this trial
- Repetitive transcranial magnetic stimulation (rTMS)
Treatment groups
30 Participants
are divided into 2 treatment groupsSponsors and collaborators
Oregon Health and Science University
Lead sponsor
National Center of Neuromodulation for Rehabilitation
Collaborator
Collins Medical Trust
Collaborator
National Institutes of Health (NIH)
Collaborator
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Collaborator
Department of Health and Human Services
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
National Center for Advancing Translational Sciences (NCATS)
Collaborator
Source ClinicalTrials.gov