The primary objective of this study is to optimize the protocol for the TUS administration in patients with TRD while gaining an initial impression of treatment efficacy.
Age between 18 and 75 years,
Diagnosis of major depressive episode (MDE) as part of major depressive disorder as defined by DSM-5 criteria
Severe MDE (HDRS-17> 20)
Drug resistance to at least two well-conducted antidepressant treatment lines
Psychiatric history other than a mood disorder
Neurological history, including epilepsy and intracerebral calcifications
History of substance use disorder other than tobacco
Contraindication to brain MRI (pacemaker, neurostimulator, injury from metallic shine, …)