Through genomic and transcriptomic sequencing techniques (whole exome sequencing, WES; whole transcriptome sequencing, WTS) patients with enrichment for KEAPness and specific gene interactions associated with it.
Age >18 years;
Histological diagnosis of NSCLC
metastatic disease
Availability, at the time of enrollment, of adequate biological material to be able to perform molecular analyses, taken (surgical or by biopsy) before administration of any anti-tumor treatment (chemotherapy and/or radiotherapy);
Previous systemic therapy for metastatic disease;
Comorbidities not controlled with adequate medical therapy.
Age >18 years;
Histological diagnosis of NSCLC