Transcriptomics as an Aid in the Histological Diagnosis of Acute Rejection After Liver Transplantation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorIRCCS Azienda Ospedaliero-Universitaria di Bologna

About this trial

The primary objective of this exploratory study is to identify genes associated with acute rejection in liver transplant patients. To this end, a panel of acute rejection indicator genes (both humoral and cell-mediated) will be selected from results published in the literature and applied to biological material derived from biopsies. The secodnary objective is to identify genes associated with the diagnosis of humoral acute rejection and those associated with the diagnosis of cell-mediated acute rejection.

Eligibility criteria

Qualifiers

Patients with a diagnosis of post-OLT rejection prior to the visit at which they will be enrolled, with tissue available for RT-PCR investigations

Age ≥ 18 years

Informed consent

Disqualifiers

Age <18 years

Trial design

Treatments tested in this trial

  • Molecular diagnostic

Treatment groups

40 Participants
are divided into 1 treatment group