Transfusion Exchanges and Cognition in Sickle Cell Disease
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCentre Hospitalier St Anne
About this trial
DREPA-COG is an observational study evaluating the effect of exchange transfusions on cognitive function in adults with severe sickle cell disease (SS or Sβ0). Information processing speed is assessed at three time points during the transfusion cycle using the Symbol Digit Modalities Test (SDMT) and additional validated neuropsychological measures. This minimal-risk, fully remote study aims to identify processing speed as a reproducible marker for clinical monitoring and future therapeutic trials.
Eligibility criteria
Qualifiers
Adults (≥18 years) with severe sickle cell disease (SS or Sβ0).
Enrolled in a regular monthly transfusion exchange program.
Not institutionalized.
No known dementia.
Disqualifiers
Insufficient mastery of spoken French.
Severe comorbidities preventing short-term follow-up.
Known psychiatric disorders.
Participation in another clinical study with ongoing exclusion periods.
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Source ClinicalTrials.gov