The use of injectable platelet-rich fibrin (i-PRF) in both surgical and non-surgical dental treatments has become increasingly widespread. Hard tissue grafts can produce "sticky bone," and bone gain can have a positive effect on intrabony defects frequently seen in periodontal disease, compared to grafts alone. This study aims to clinically and radiographically evaluate the effectiveness of using bovine-derived xenogenic bone grafts in combination with i-PRF and bovine-derived xenogeneic bone grafts alone in patients with intrabony defects and stage III periodontitis.
Male and female patients aged 18-65 years
Patients with Stage III Periodontitis according to the AAP-EFP 2017 Periodontal Disease Classification
PPD≥5 mm (if persistent 6 weeks after initial periodontal treatment)
Intrabony defects in the interproximal region with 2 or 3 walls and a depth of at least ≥3 mm
Patients under 18 years of age or older than 65 years of age
Patients unable to consent
Systemic diseases that could affect the success of surgery, such as uncontrolled diabetes
Single-walled intrabony defects