Treatment of Oral Lichen Planus With Paeoniflorin and Photodynamic Therapy
ConditionOral Lichen Planus
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorPeking University Third Hospital
About this trial
Oral lichen planus (OLP) is a common chronic inflammatory disease of the oral mucosa and is considered a precancerous condition. It is characterized by white reticular changes in the oral mucosa, which can progress to erosions and cause pain in severe cases. The pathogenesis of OLP is still unclear, but it is believed to be a T-lymphocyte-mediated autoimmune disease. Currently, only symptomatic treatments are available, and there is no definitive cure.
In this project, we plan to use TCM differentiation to categorize OLP patients and conduct a randomized controlled clinical trial to demonstrate the enhanced therapeutic effect of paeoniflorin combined with photodynamic therapy for OLP. The implementation of this project will provide new insights into the clinical management of OLP, improve our understanding of the treatment mechanisms, and have important theoretical and clinical implications.
Eligibility criteria
Qualifiers
patients with oral lichen planus
male or female patients older than 18 years of age
patients willing to participate with signed informed consent.
Disqualifiers
pregnant or lactating
had serious systemic diseases of the heart, lung, liver, and kidney, or had tumors
were unwilling to participate in the experiment.
Trial design
Treatments tested in this trial
- total glucosides of paeony treatment
- photodynamic therapy treatment
- glucosides of paeony and photodynamic therapy combined treatment
Treatment groups
156 Participants
are divided into 3 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov