Treatment of Perioperative Neurocognitive Disorders With Olfactory Enrichment
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorShanghai 10th People's Hospital
About this trial
Perioperative neurocognitive disorder (PND) is one of the most common postoperative complications among elderly patients. However, the mechanism and targeted intervention of PND remains unclear. Our previous clinical studies demonstrated the association between olfactory impairment and PND. Moreover, our translational studies showed that anesthesia/surgery induced olfactory impairment and caused cognitive impairment in mice and olfactory enrichment could prevent the anesthesia/surgery-induced cognitive impairment. However, there was no clinical investigation to determine whether olfactory enrichment can mitigate PND in elderly patients. Therefore, we propose determining whether olfactory enrichment can prevent and/or treat PND in elderly patients.
Eligibility criteria
Qualifiers
Age ≥65 years old.
Having a scheduled surgery (≥2 hours, general anesthesia) (e.g., total hip replacement, toal knee replacement, open reduction and internal fixation of hip and lumbar spine).
Being able to complete neuropsychological tests, 3D-CAM and CAM-S.
Chinese Mandarin as their native language.
Disqualifiers
Having delirium, assessed by 3D-CAM, before surgery.
Having a brain tumour, stroke or mental disorders (eg, major depressive disorder or dementia).
Participating in other clinical studies at the time of screening.
Unwillingness to comply with the protocol or procedures.
Trial design
Treatments tested in this trial
- Olfactory Enrichment
- Sham
Treatment groups
686 Participants
are divided into 2 treatment groupsSponsors and collaborators
Shanghai 10th People's Hospital
Lead sponsor
National Natural Science Foundation of China
Collaborator
Source ClinicalTrials.gov