About this trial
To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.
Eligibility criteria
Qualifiers
Age 18-80.
Spontaneous SAH confirmed by head CT.
Saccular brain aneurysm is identified and treated, either surgically or endovascularly.
SAH Fisher grade >1 or modified Fisher grade >0.
Disqualifiers
Hunt-Hess Grade 5 or WFNS Grade 5 (no clinical improvement after EVD placement for acute hydrocephalus).
Bacterial or distal aneurysms without subarachnoid hemorrhage in the basal cisterns.
The treating physician determines that the culprit aneurysm has not been fully repaired, with a very high likelihood of rebleeding in the near term.
History of head trauma within the past 3 months.
Trial design
Treatments tested in this trial
- Intrathecal Nicardipine
- No intervention