Treatment of Vasospasm of Aneurysmal Subarachnoid Hemorrhage With Intrathecal Nicardipine - FAST-IT Trial

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorThe Affiliated Hospital Of Guizhou Medical University

About this trial

To investigate whether patients with cerebral vasospasm associated with aneurysmal subarachnoid hemorrhage have a better prognosis with intrathecal nicardipine injection via extraventricular drainage or lumbar drainage.

Eligibility criteria

Qualifiers

Age 18-80.

Spontaneous SAH confirmed by head CT.

Saccular brain aneurysm is identified and treated, either surgically or endovascularly.

SAH Fisher grade >1 or modified Fisher grade >0.

Disqualifiers

Hunt-Hess Grade 5 or WFNS Grade 5 (no clinical improvement after EVD placement for acute hydrocephalus).

Bacterial or distal aneurysms without subarachnoid hemorrhage in the basal cisterns.

The treating physician determines that the culprit aneurysm has not been fully repaired, with a very high likelihood of rebleeding in the near term.

History of head trauma within the past 3 months.

Trial design

Treatments tested in this trial

  • Intrathecal Nicardipine
  • No intervention

Treatment groups

396 Participants
are divided into 2 treatment groups