Triage and Recognition of Acute Aortic Dissection in Chest Pain by Electrocardiogram-Artificial Intelligence

Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-80
SponsorShanghai Zhongshan Hospital

About this trial

The goal of this prospective multicenter observational study is to learn whether an artificial intelligence model based on electrocardiograms (ECGs) can help diagnose acute type A aortic dissection (TAAD) in adults who come to the emergency department with chest pain or related symptoms. The main question it aims to answer is:

Can the AI-ECG model accurately distinguish TAAD from other causes of chest pain in a real-world emergency setting? Researchers will compare the AI model's ECG-based predictions with the final diagnosis confirmed by computed tomographic angiography (CTA), which is the reference standard. Participants will undergo routine emergency ECG testing and subsequent diagnostic evaluation as part of standard care. Clinical and ECG data will be collected from five tertiary hospitals, and the model's diagnostic performance will be assessed across centers.

Eligibility criteria

Qualifiers

Male or female emergency department patients aged 18-80 years;

Clear presentation of chest pain or related chest/back pain;

Completion of standard 12-lead electrocardiography (ECG) within 24 hours after onset of chest pain;

ECG signal quality meeting the following criteria: QRS amplitude ≥ 0.1 mV and noise proportion < 20%;

Disqualifiers

Poor-quality ECG recordings, defined as missing leads in ≥ 3 leads or severe baseline instability;

Indeterminate final diagnosis;

History of prior surgery involving the aortic valve, aortic root, or ascending aorta.

Trial design

Treatments tested in this trial

  • Not listed

Trial groups

10,000 Participants
are grouped into 2 trial groups

Locations

This trial has no locations

Sponsors and collaborators

Shanghai Zhongshan Hospital

Lead sponsor

Yan'an Affiliated Hospital of Kunming Medical University

Collaborator

Taian City Central Hospital

Collaborator

Mianyang Central Hospital

Collaborator

Guangdong Provincial People's Hospital

Collaborator