The hypothesis is that the Spontaneous Breathing Test (SBT) without pressure support (PS) is not inferior to the SBT with pressure support in relation to the following outcomes: a) extubation failure; b) time on MV.
The main objective of this study is to determine whether SBT without PS is non-inferior to SBT with PS in relation to the primary outcome: a) extubation failure; and secondary outcomes: b) length of stay in the PICU and c) days free of MV.
Pacients will be randomized to 2 arms:
1. SBT with PS 2. SBT without PS (with PEEP only)
Patients admitted to the PICU on MV for more than 24 hours
Patients over 1 month old (corrected gestational age > 38 weeks) and < 18 years old on the day of screening for ERT
Perinatal-related lung disease
Congenital diaphragmatic hernia or congenital/acquired paralysis of the diaphragm
Children with heart disease
Primary pulmonary hypertension