Health Trials

TUBectomy With Delayed Oophorectomy in High Risk Women to Assess the Safety of Prevention

ConditionsBRCA1 Gene MutationBRCA2 Gene MutationRAD51C Gene MutationRAD51D Gene MutationBRIP1 Gene MutationOvarian Cancer
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexFemale
Age25-50
SponsorUniversity Medical Center Nijmegen

About this trial

The aim of the project is to evaluate the risk-reducing salpingectomy with delayed oophorectomy as an alternative for risk-reducing salpingo-oophorectomy in high risk women with respect to ovarian cancer incidence.

Eligibility criteria

Qualifiers

Women with a class 5 (definitely pathogenic) BRCA1, BRCA2, RAD51C, RAD51D or BRIP1 germline mutation in one of the participating centers.

Age at inclusion;

BRCA1: 25-40 years

BRCA2: 25-45 years

Disqualifiers

Postmenopausal status (natural menopause or due to treatment)

Wish for second stage RRO within two years after RRS

Legally incapable

Prior bilateral salpingectomy

Trial design

Treatments tested in this trial

  • Risk-reducing salpingectomy with delayed oophorectomy
  • Risk-reducing salpingo-oophorectomy

Treatment groups

3,000 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University Medical Center Nijmegen

Lead sponsor

Source ClinicalTrials.gov