Tumor-Derived Extracellular Vesicles for Noninvasive Molecular Classification of Kidney Cancer

ConditionsRenal Cell Carcinoma Clear-cell Renal Cell Carcinoma Papillary Renal Cell Carcinoma Chromophobe Renal Cell Carcinoma Kidney Cancer

Trial statusNot yet recruiting

Trial phaseNot listed

Trial typeObservational

Biological sexAll

AgeNot listed

SponsorMayo Clinic

About this trial

This is a correlative (lab-based) study aiming to identify protein markers in urine extracellular vesicles (EVs) that can be used to develop non-invasive molecular tests for patients with renal cell carcinoma (RCC). Aim 1 will use urine collected previously in biorepository. Aim 2 will prospectively collect blood specimens pre and post nephrectomy.

Eligibility criteria

Qualifiers

Urine sample in existing biorepository

High-risk renal cell carcinoma (RCC) per American Urological Association (AUA) guidelines

Scheduled to undergo nephrectomy

Disqualifiers

Does not meet inclusion criteria

Trial design

Treatments tested in this trial

Proteomic profiling of urinary EVs
Blood sample collection

Treatment groups

300 Participants

are divided into 4 treatment groups

Sponsors and collaborators

Mayo Clinic

Lead sponsor

Source ClinicalTrials.gov