UK CARDIOvascular Immune-Mediated Inflammatory Diseases (CARDIO-IMID) Registry Study
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity of Manchester
About this trial
The goal of this observational study is to develop a large, deeply characterised cohort that will be a platform for collaborative clinical and translational research into cardiovascular (CV) disease (CVD) and Immune-mediated-inflammatory-diseases (IMID). The main aim is to evaluate whether existing blood cardiac biomarkers predict adverse cardiovascular outcomes. The study will capture standard of care CV and associated health data (clinical, biochemistry/pathology and investigations) in patients across the IMIDs. Optional biological and/or imaging sub-studies will provide additional data and/or samples for associated analyses.
Eligibility criteria
Qualifiers
Written informed consent
Coronary artery disease (CAD): specifically, a high pre-test probability of CAD based on clinical risk factors (e.g. QRISK3 score ≥10%) and/or elevated biochemical markers (high-sensitivity C-reactive protein ≥2mg/L and/or Lipoprotein(a) ≥70mg/dL)
Myopericardial involvement: Specific IMID and/or cardiovascular indicators that place at increased risk e.g. autoantibody associations, presence of peripheral myositis or other major organ involvement; incidental raised serum cardiac biomarkers (troponin and/or NT-pro BNP), on routine testing
Deep vein thrombosis (VTE) and/or pulmonary embolism [PE].
Disqualifiers
Age less than 18 years
Unable to give informed consent
CMR: metal implant eg metal fragments in the eye, pacemaker; claustrophobia; inability to lie flat
Magnetic Resonance Imaging (MRI) contrast: renal failure with estimated glomerular filtration rate (eGFR) <30,
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
University of Manchester
Lead sponsor
University of Cambridge
Collaborator
University of Oxford
Collaborator
University of Edinburgh
Collaborator
University of Leeds
Collaborator
Imperial College London
Collaborator
Medical Research Council
Collaborator
British Heart Foundation
Collaborator
Swansea University
Collaborator
British Heart Foundation Data Science Centre
Collaborator
Source ClinicalTrials.gov