UK Heart Failure With Preserved Ejection Fraction
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorManchester University NHS Foundation Trust
About this trial
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF.
HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited.
UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
Eligibility criteria
Qualifiers
Written informed consent
Diagnosis of HFpEF by a cardiologist with HF expertise, or a primary care physician with HF expertise, or a heart failure nurse
Natriuretic peptide levels measured
Disqualifiers
LV EF < 40% (at screening or any previous measurement)
Known infiltrative cardiomyopathy (e.g., amyloid, sarcoid, lymphoma, endomyocardial fibrosis)
Known active myocarditis, constrictive pericarditis, or cardiac tamponade
Known genetic hypertrophic cardiomyopathy or obstructive hypertrophic cardiomyopathy
Trial design
Treatments tested in this trial
- Not listed
Trial groups
No trial groups listed
Sponsors and collaborators
Manchester University NHS Foundation Trust
Lead sponsor
Pumping Marvellous Foundation
Collaborator
British Society for Heart Failure
Collaborator
National Institute for Health Research, United Kingdom
Collaborator
British Heart Foundation Data Science Centre
Collaborator
Source ClinicalTrials.gov