The purpose of this retrospective and prospective multicenter study is to evaluate the incidence of pulmonary hypertension (PH) within 6 months from ultrasound-assisted, Catheter-directed Thrombolysis for acute intermediate- high-risk Pulmonary Embolism
Patients admitted with acute intermediate-high risk PE, defined according to ESC guidelines
Symptoms onset within previous 14 days associated or not with deep venous thrombosis
Confirmation of the PE by contrast-enhanced computed tomography of the chest with embolus located in at least one main or proximal lower lobe pulmonary artery
Echocardiographic parameters of RV disfunction
Age < 18 years old
Patients unable to give informed consent
Pregnancy
Patients received fibrinolytic drugs in the preceding 4 days