Unintentional Weight Loss and Cancer: A Prospective Trial of Patient-centered Weight Tracking Combined With GRAIL Galleri Testing to Improve Early Detection

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age40-80
SponsorCase Comprehensive Cancer Center

About this trial

Unintentional weight loss (UWL) is commonly associated with a wide variety of diseases and there is still no valid diagnostic pathway for evaluating UWL. When detecting UWL coupled with GRAIL Galleri testing, (an investigational pan-cancer early detection test), it is thought that there is a greater positive predictive value in detecting malignancies. This study aims to test the potential synergistic effects of UWL detection and GRAIL usage to detect malignancy at an even earlier rate. UWL will be measured using weekly weight tracking.

Eligibility criteria

Qualifiers

Age range: from 40 to 80 years

Access to a device (cellphone, computer, tablet) that is compatible with the Fitbit Aria Air smart scale utilized in this study

Willing to comply with all study procedures and be available for the duration of the study

Subjects must be mentally competent and must have the ability to understand and the willingness to sign a written informed consent document

Disqualifiers

Active cancer diagnosis - current diagnosis, currently undergoing cancer treatment, or concluded cancer treatments within 3 years

Actively trying to lose weight with medications or bariatric surgery

Pregnant

Trial design

Treatments tested in this trial

  • GRAIL Galleri

Treatment groups

1,000 Participants
are divided into 1 treatment group

Sponsors and collaborators

Case Comprehensive Cancer Center

Lead sponsor

University Hospitals Seidman Cancer Center

Collaborator