This case-control study aims to investigate the genetic and molecular bases of nicotine addiction to identify potential therapeutic targets. The project will involve drug repurposing using Mendelian Randomization, a smoking cessation intervention, and the analysis of methylation status in participants undergoing nicotine withdrawal.
Adults aged 18-60 years old
Current daily cigarette smoker
Able to understand study procedures and provide informed consent
For females, non-pregnant and non-lactating
Presence of significant uncontrolled medical conditions (e.g. cardiovascular disease, respiratory disorders, cancer) that could affect smoking behaviors or study participation
Presence of major uncontrolled psychiatric disorders (e.g. schizophrenia, bipolar disorder, severe depression)
Current substance use disorder (except nicotine dependence)
Taking medications that could significantly interfere with study objectives (e.g. medications for smoking cessation)