Unruptured Cerebral Aneurysm: Prediction of Evolution
ConditionUnruptured Intracranial Aneurysm
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorNantes University Hospital
About this trial
The protocol has many assets. A prospective nationwide recruitment allows for the inclusion of a large cohort of patients with UIA. It will combine accurate clinical phenotyping and comprehensive imaging with CAWE screening. Besides, it will enable to exploit metadata and to explore new pathophysiological pathways of interest by crossing clinical, genetic, biological, and imaging information.
Eligibility criteria
Qualifiers
Subject carrying unruptured, asymptomatic and untreated typical IA of bifurcation, measured on conventional imaging (MRI, CTA or DSA) between 3 and 7 mm of larger diameter.
Ability to be followed-up during 3 years decided in consensus multidisciplinary gathering.
Age > 18 years old.
Disqualifiers
A failure to obtain informed consent
Contraindications for undergoing an MRI scan include : (heart pacemaker, a metallic foreign body (metal sliver) in their eye, or aneurysm clip in their brain, severe claustrophobia)
Contraindications for a gadolinium contrast medium injection (:eGFR below 30 mL/min/1.73 m2, Previous or pre-existing nephrogenic systemic fibrosis, Previous anaphylactic/anaphylactoid reaction to gadolinium containing contrast agent, Acutely deteriorating renal function, Pregnancy and breast-feeding)
A mycotic, fusiform-shaped, or dissecting IA, an IA in relation with an arteriovenous malformation
Trial design
Treatments tested in this trial
- Unruptured intracranial aneurysms
Treatment groups
No treatment groups listed
Sponsors and collaborators
Nantes University Hospital
Lead sponsor
Centre Hospitalier St Anne
Collaborator
Source ClinicalTrials.gov