Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorUniversity of Florida
About this trial
Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.
Eligibility criteria
Qualifiers
Age 65+
Objective executive function decline, based on standardized cognitive assessments.
Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
Ability to walking independently for 6 minutes (use of cane permitted)
Disqualifiers
Major cognitive disorder that interferes with independence
Percentile score less than 10th percentile on standardized cognitive assessments
Medications that are thought to influence tDCS neuroplasticity.
Contraindications to tDCS or MRI.
Trial design
Treatments tested in this trial
- Walking Exercise
- Prefrontal Active tDCS
- Prefrontal Sham tDCS
Treatment groups
120 Participants
are divided into 2 treatment groupsSponsors and collaborators
University of Florida
Lead sponsor
National Institute on Aging (NIA)
Collaborator
Source ClinicalTrials.gov