Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-70
SponsorCliniques universitaires Saint-Luc- Université Catholique de Louvain
About this trial
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS). The main questions it aims to answer are:
* Is the type 2 inflammation impacting the olfactory epithelium regeneration, leading to OD? * Does a treatment interfering with one of the major T2 inflammatory cytokines, have an impact on the mechanisms of OD in CRS?
Participants will undergo olfactory testing and nasal brushing before and after 3 months of treatment.
Eligibility criteria
Qualifiers
At least two of the following symptoms: nasal obstruction, rhinorrhoea, smell loss, facial pain for 12 weeks.
Endoscopic visualisation of bilateral sinonasal polyps
SSI (TDI) < 30.75 and decreased sense of smell subjectively
Eosinophilia > 300/μl of blood Ku/l
Disqualifiers
Active smoking
Primary and secondary immune deficiencies
Ciliary diseases (cystic fibrosis, primary ciliary diskinesia)
History of or current nasal malignancies
Trial design
Treatments tested in this trial
- Nasal brushing of the olfactory cleft
- Smell testing
Treatment groups
140 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov