Uppsala Psychosis Cohort
ConditionSchizophrenia; Psychosis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-40
SponsorUppsala University
About this trial
A multimodal longitudinal study in early stage psychosis patients and individuals at high risk for psychosis. Healthy controls are included for baseline comparisons. The aim is to investigate disease mechanisms of psychotic disorders, specifically focusing on the synaptic pruning hypothesis.
Eligibility criteria
Qualifiers
Diagnosis as assessed using DSM-5 of one of the following: schizophrenia, schizophreniform psychosis, psychosis not otherwise specified (NOS), brief psychosis, schizoaffective syndrome, delusional disorder
Onset of psychotic symptoms together with functional decline no more than 3 years prior to inclusion visit
Disqualifiers
Other dominant psychiatric illness that is deemed to be related to current psychotic symptoms (including bipolar disorder, major depressive disorder, autism)
Long-term daily treatment (<2 weeks) with benzodiazepines, such that there is an inability to refrain from treatment during testing procedures.
A history of diagnosis of a major psychiatric disorder, including substance use disorders.
A family history of psychotic disorders or bipolar disorder in first degree relatives.
Trial design
Treatments tested in this trial
- No intervention
Treatment groups
120 Participants
are divided into 3 treatment groupsSponsors and collaborators
Uppsala University
Lead sponsor
Uppsala University Hospital
Collaborator
Source ClinicalTrials.gov