Urea for Treatment of Hyponatremia in Patients With SIAD Unresponsive to Fluid Restriction
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorUniversity of Turin, Italy
About this trial
Hyponatremia due to SIAD is frequently insufficiently corrected by fluid restriction alone, which remains the first-line therapy but is often poorly tolerated. Urea supplementation is recommended as second-line therapy.
This prospective study evaluates the effectiveness of oral urea supplementation in patients with chronic SIAD and persistent hyponatremia despite fluid restriction.
Eligibility criteria
Qualifiers
Plasma sodium concentration <135 mmol/L
Plasma osmolality <300 mOsm/kg
Urine osmolality >100 mOsm/kg
Urine sodium concentration >30 mmol/L
Disqualifiers
Chronic hypotonic hyponatremia secondary to another etiology
Presence of moderate to severe symptoms attributable to plasma hypotonicity
Severe hypotonic hyponatremia (serum sodium <120 mmol/L)
Another ongoing drug treatment for hyponatremia (including vaptans and salt tablets)
Trial design
Treatments tested in this trial
- urea
Treatment groups
20 Participants
are divided into 1 treatment groupSponsors and collaborators
Source ClinicalTrials.gov