About this trial
This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.
Eligibility criteria
Qualifiers
Age 19-70 years.
C-reactive protein (CRP) > 5 mg/L; or
Fecal calprotectin (FCP) > 200 µg/g.
Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment.
Disqualifiers
Partial Mayo score (pMayo) > 7.
Pregnant or breastfeeding.
Body mass index (BMI) < 18 kg/m².
History of an eating disorder.
Trial design
Treatments tested in this trial
- Elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA)
- Reduced Sulfur diet
- Habitual Diet
Treatment groups
Sponsors and collaborators
University of British Columbia
Lead sponsor
University of Calgary
Collaborator