Using Breath Tests to Study Gut Sulfur Changes During Dietary Therapy

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age19-70
SponsorUniversity of British Columbia

About this trial

This study aims to test whether a short liquid-based diet, followed by a low-sulfur eating plan, is safe, manageable, and helpful for people with mild to moderate ulcerative colitis. Investigators want to see if this approach can improve gut health, lower inflammation, and reduce symptoms. Investigators will also test breath samples as an easy, non-invasive way to track gut bacteria activity and disease changes. Investigators believe this diet plan can reduce harmful gut bacteria that produce irritating sulfur compounds, leading to better gut health and measurable improvements that can be detected through breath testing.

Eligibility criteria

Qualifiers

Age 19-70 years.

C-reactive protein (CRP) > 5 mg/L; or

Fecal calprotectin (FCP) > 200 µg/g.

Receiving stable medical therapy for ulcerative colitis for at least 8 weeks prior to enrollment.

Disqualifiers

Partial Mayo score (pMayo) > 7.

Pregnant or breastfeeding.

Body mass index (BMI) < 18 kg/m².

History of an eating disorder.

Trial design

Treatments tested in this trial

  • Elemental formula (mBiota Elemental, Good LFE, Santa Monica, CA)
  • Reduced Sulfur diet
  • Habitual Diet

Treatment groups

45 Participants
are divided into 2 treatment groups

Sponsors and collaborators

University of British Columbia

Lead sponsor

University of Calgary

Collaborator