This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.
Age between 65 and 84 years old;
Weight ≥ 110 pounds;
Nonsmokers for at least 1 year;
Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;
Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;
Currently have active cancer treatments;
The residential house has already had HEPA filters;
Participants will move out from the current residential address in the next 2 years;
University of Southern California
Lead sponsor
Duke University
Collaborator
National Institute of Environmental Health Sciences (NIEHS)
Collaborator