Utilizing Anti-Factor Xa as a Predictive Tool for Optimizing Outcome in Burn Patients' Management

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21+
SponsorAin Shams University

About this trial

This study aims to compare the efficacy of anti-Xa based versus weight-based enoxaparin dosing and to evaluate anti-Xa levels as a predictive tool for clinical outcomes in burn patients

Eligibility criteria

Qualifiers

Adults (≥21 years) admitted to the burn unit with thermal burns ≥20% TBSA and < 60%.

Admission to BICU within 48 hours of burn injury.

Indication for VTE prophylaxis (e.g., immobilized, surgical intervention).

Ability to provide informed consent

Disqualifiers

Pre-existing coagulopathy or anticoagulant therapy prior to injury.

Patients with severe comorbidities (e.g., end-stage renal failure, advanced malignancy, hepatic disease).

Need for therapeutic anticoagulant therapy.

patients with extremes of weight, (45kg >=weight >= 150kg).

Trial design

Treatments tested in this trial

  • follow up venous thrombo embolic events with routine clexan dose modification guided by anti factor 10 assay
  • follow up venous thromboembolic events with no routine clexan dosage modification and no usage of anti factor 10 assay

Treatment groups

25 Participants
are divided into 2 treatment groups

Sponsors and collaborators