The present study aims to compare effectiveness and cost-effectiveness of the miRFec test with respect to fecal immunochemical test (FIT) for the detection of advanced colorectal neoplasm among individuals participating in colorectal cancer (CRC) screening, surveillance and diagnosis.
Male or female aged 50 to 75 (average-risk) referred to colonoscopy-based CRC screening.
Male or female aged 30 to 80 with family history of CRC (moderate-risk) referred to colonoscopy-based CRC screening.
Male and female aged 18 or older with personal history of colorectal polyps referred to colonoscopy surveillance.
Male and female aged 18 or older with personal history of CRC referred to colonoscopy surveillance.
Lack of informed consent to participate
Personal history of Lynch syndrome
Personal history of adenomatous or hamartomatous polyposis
Personal history of serrated polyposis syndrome