This study will use an observational cohort to cross-sectionally and longitudinally relate vascular health to clinical, imaging, and biological markers of early Alzheimer's disease and cerebrovascular disease among aging adults. Adjusting for relevant clinical covariates, we will test the hypothesis that vascular health is associated with clinical, brain magnetic resonance imaging (MRI), neuropsychological, and cerebrospinal fluid markers of early cerebrovascular and Alzheimer's disease changes (i.e., prior to the onset of significant cognitive decline or dementia). Secondarily, we will examine medical and genetic factors that might mediate associations between vascular health and brain aging, such as inflammatory processes, insulin resistance, and genetic factors (e.g., APOE, a susceptibility risk factor for dementia). Findings will advance knowledge regarding the role that vascular health plays in brain aging.
Participants recruited will include 1,000 adults age 50 and older.
After the eligibility visit, a small portion of participants (~150) enrolling must meet diagnostic criteria for mild cognitive impairment according to a clinician diagnosis and/or medical records (i.e., participants must have mild memory or cognitive problems, but they must be free of any functional problems and not have Alzheimer's disease or another form of dementia). The remaining ~850 participants will be cognitively unimpaired adults age 50 and older.
Because the neuropsychological tests used to measure cognitive performance are validated on English-speaking populations, we require that English be the primary language of all participants.
No available reliable study partner
History of major psychiatric illness (e.g., schizophrenia, bipolar), neurological illness (e.g., stroke, epilepsy, multiple sclerosis, Parkinson's disease, dementia), or head injury with significant loss of consciousness. These exclusion criteria have been applied because they affect brain structure and function.
Diagnosis of congestive heart failure
Diagnosis of atrial fibrillation or other heart arrhythmia
Community-dwelling older adults.
Case-control
Prospective
none, observational study
Other interventionnone, observational study
White matter hyperintensities Volume
White matter lesion volume measured by FLAIR imaging modality
Grey Matter Volume
Grey matter volume measured by T1 imaging modality
Cerebral Blood Flow
Resting cerebral blood flow to brain regions measured by T3 perfusion
Lacunar infarcts
Number of lacunar infarcts measured by MRI
Click on the lead sponsor to view all of their trials.
Vanderbilt University Medical Center
Lead sponsor
National Institute on Aging (NIA)
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
