Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorKarolinska Institutet
About this trial
Study objectives:
* To assess the impact of mitral valve surgery for mitral regurgitation on ventricular arrhythmic burden and surrogate markers of fibrosis in patients with arrhytmogenic mitral valve prolapse (MVP) from baseline to 6 months after surgery * To characterize the molecular landscape of arrhytmogenic MVP
Study design:
-Prospective explorative observational study
Study population:
-90 patients with arrhytmogenic MVP and without arrhytmogenic MVP (controls) eligible for mitral valve surgery for mitral regurgitation will be enrolled. All patients will be evaluated with cardiac magnetic resonance (CMR) imaging and continuous seven day arrhythmic monitoring before and at 6 months after mitral valve surgery
Eligibility criteria
Qualifiers
Age 18 and over
Patients with and without (controls) arrhythmogenic MVP in need of mitral valve surgery for primary mitral regurgitation according to current standard of care
Disqualifiers
Secondary mitral regurgitation
Primary mitral regurgitation not due to degenerative disease (including rheumatic disease)
Co-existing moderate or severe aortic valve disease
Congenital heart disease
Trial design
Treatments tested in this trial
- Mitral valve surgery
Treatment groups
90 Participants
are divided into 1 treatment groupSponsors and collaborators
Karolinska Institutet
Lead sponsor
Karolinska University Hospital
Collaborator
Source ClinicalTrials.gov