This observational study involving patients with acute brain injury undergoing treatment with an external ventricular drain consists of three subprojects, aiming to:
1. investigate various biomarkers, with a primary focus on the development of cerebrospinal fluid lactate in relation to ventriculostomy-associated infection; 2. compare proximal and distal sample results obtained from an external ventricular drain; 3. describe the natural progression of various biomarkers in blood and cerebrospinal fluid following acute brain injury.
Age >18 years
EVD in situ
Admission to the neuro-ICU or neurosurgical step-down unit at Rigshospitalet, Denmark
Diagnosis of acute brain injury categorized as traumatic brain injury, subarachnoid haemorrhage, intracranial haemorrage, intraventricular haemorrhage
Patient or closest relatives do not understand written and spoken Danish or English
Patients transferred to Rigshospitalet with an EVD
Patients with brain injury due to existing brain infection (e.g., meningitis, intracranial empyema or abscess, encephalitis)
Patients with existing ventriculoperitoneal or ventriculoatrial shunt at the time of admission