Vericiguat for Heart Failure With Reduced Ejection Fraction After Myocardial Infarction
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorQilu Hospital of Shandong University
About this trial
The effects of vericiguat on cardiac remodeling in patients with chronic stable heart failure after myocardial infarction have not been reported. This project aims to clarify the efficacy and safety of vericiguat in patients with chronic heart failure after myocardial infarction. Patients with chronic stable heart failure with reduced ejection fraction after myocardial infarction in the electronic medical records of Qilu Hospital of Shandong University will be selected and divided into two groups: the treatment group received vericiguat in addition to conventional treatment and the control group received conventional treatment only. After 12-month treatment, the effects of vericiguat on cardiac remodeling and function and cardiovascular adverse events will be evaluated. The results are helpful to provide a new treatment strategy for chronic heart failure after myocardial infarction.
Eligibility criteria
Qualifiers
The history of acute myocardial infarction exceeds 3 months;
Symptoms and signs of heart failure have been stable for more than one month;
18 years old or more;
NYHA cardiac function classified as grade II~IV;
Disqualifiers
Patients with the following diseases: nonischemic cardiomyopathy; valvular heart disease; congenital heart disease; obstruction of left ventricular outflow tract; severe decompensated heart failure; active myocarditis or pericardial disease; end-stage liver and kidney diseases; malignant tumor;
Mechanical complications of myocardial infarction;
Unable to obtain primary outcome data.
Trial design
Treatments tested in this trial
- Vericiguat Oral Tablet [Verquvo]
- Prescription Drugs
Treatment groups
210 Participants
are divided into 2 treatment groupsSponsors and collaborators
Qilu Hospital of Shandong University
Lead sponsor
Jinan Central Hospital
Collaborator
Qianfoshan Hospital
Collaborator
Source ClinicalTrials.gov