This study will evaluate the role of SBRT with the aim to reproduce high dose rate brachytherapy (HDR BT) dose distribution by means of external beam radiotherapy in the radical treatment in patients with LACC. The study will employ devices to accurately reproduce pelvic anatomy and mitigate target motion and will make use of real-time online tracking.
Cancer of the uterine cervix suitable for curative treatment with definitive radio-chemotherapy
Biopsy proven showing squamous-cell carcinoma, adenocarcinoma or adeno-squamous cell carcinoma of the uterine cervix.
Pelvic MRI.
MRI and Positron emission tomography (PET-CT) of the retroperitoneal space and abdomen at diagnosis is performed.
Other primary malignancies except carcinoma in situ of the cervix and basal cell carcinoma of the skin.
Small cell neuroendocrine cancer, melanoma and other rare cancers in the cervix.
Metastatic disease above and beyond the retroperitoneal paraaortic L1-L2 interspace.
Previous pelvic or abdominal radiotherapy.