Virtual Contexts for Affective Modulation

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-55
SponsorTrustees of Dartmouth College

About this trial

This study investigates how spatial context and perceived controllability modulate pain, affective states such as anxiety, and motivated behavior. The study examines how control over pain and threat-related environments influences pain perception, state anxiety, associated autonomic responses, and behavior. The main questions it aims to answer are:

Does having control over pain within specific contexts alter how much pain people feel-even when the stimulus intensity remains constant? How do different types of environments (safe, controllable, or uncontrollable) shape pain-related brain activity, subjective anxiety, and physiological arousal? How do people perform cognitively demanding or distracting tasks (and retain their memory) when under threat versus when in control? Lastly, how do these learned associations with spatial contexts persist or adapt when environmental contingencies are explicitly changed?

Taken together, exploration of these factors may lay the groundwork for understanding how placebo-related mechanisms-including perceived control, contextual learning, emotional engagement, and distraction-interact to shape pain and anxiety in complex environments.

Eligibility criteria

Qualifiers

No self-reported current or history of depression, bipolar disorder, or other psychiatric diagnosis

No self-reported current seizure disorder (i.e., seizure within past 10 years), or history of stroke or other major neurological diagnosis

No self-reported current chronic pain, or acute pain within three months of the study period

No current migraine disorder (i.e., 15 headache days or more in 1 month)

Disqualifiers

None

Trial design

Treatments tested in this trial

  • Pain Threat Manipulation
  • Pain Controllability Manipulation

Treatment groups

20 Participants
are divided into 1 treatment group

Sponsors and collaborators