VITAL: Vaccination, Immunity, Time-restricted Eating, Aging and Lifestyle
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age60-85
SponsorCharite University, Berlin, Germany
About this trial
The aim of this study is to investigate the effects of a four-week time-restricted eating (TRE) intervention on autophagy, immune function, and vaccine response to a seasonal influenza and COVID-19 vaccines in older healthy subjects.
Eligibility criteria
Qualifiers
Male and female participants, enrolled in a 1:1 ratio
Age 60-85 years
Body mass index (BMI) 20-35 kg/m²
Capacity to give informed consent
Disqualifiers
Any vaccination (especially influenza and/or COVID-19) within 6 months before the intervention start
Vaccinations not related to the study, administered during the study period from V0 to V4
History of influenza infection within 6 months prior to initiation of the study intervention
History of severe adverse reactions to prior vaccinations
Trial design
Treatments tested in this trial
- TRE: Time-restricted eating
Treatment groups
24 Participants
are divided into 2 treatment groupsSponsors and collaborators
Charite University, Berlin, Germany
Lead sponsor
Max Delbrück Center for Molecular Medicine (MDC), Berlin
Collaborator
Labor Berlin, Germany
Collaborator
Experimental & Clinical Research Center Berlin
Collaborator
University of Oxford
Collaborator
University of Cologne
Collaborator
Source ClinicalTrials.gov