The goal of this clinical trial is to learn whether learning and belief updating change in response to the treatment of persecutory delusions, in individuals with schizophrenia-spectrum disorders.
The main questions are:
1. do prior expectations about environmental volatility reduce following effective psychotherapeutic treatment of delusions? 2. does corresponding brain activity related to volatility change with effective treatment of delusions?
Participants will:
1. engage in CBTp or TAU + phone check-ins for 16 weeks 2. complete assessments at 4 timepoints over the course of 6 months 3. complete an MRI when possible
Men and women age 18 - 65.
Communicative in English.
Premorbid IQ >79 (WTAR)
Provide voluntary, written informed consent.
Serious medical or neurological illness known to interfere with cognitive functioning (uncontrolled/unstable diabetes, uncontrolled hypothyroidism, Cushing's disease, Lupus, any demyelinating disease such as Multiple Sclerosis, HIV infection, CNS infection, unstable heart disease, active hepatitis, other significant endocrine condition, any cancer involving the CNS/brain, any uncorrected vision problems, tardive dyskinesia).
History of severe head trauma with loss of consciousness >30 minutes.
Primary diagnosis of alcohol or substance use disorder or personality disorder
Vanderbilt University Medical Center
Lead sponsor
National Institute of Mental Health (NIMH)
Collaborator