Watch and Wait as Treatment for Patients With Rectal Cancer

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorSahlgrenska University Hospital

About this trial

A national cohort study with all patients scheduled for neoadjuvant treatment with (chemo)radiotherapy or short course radiotherapy with delayed surgery 6-8 weeks) for rectal cancer staged as cT4bNX/anycTanycN and cMRF+/anycTanycN and lateral lymph nodes on MRI (and patients that have been offered short course raditotherapy with delayed surgery due to various reasons). The tumours are positioned midrectal or low and are palpable with the finger. The patients offered this treatment after recommendations on their local multidisciplinary tumour board will be will be informed and offered to participate in the study. Patients scheduled for short course radiotherapy with immediate surgery cannot be included.

Eligibility criteria

Qualifiers

cT4bNX

anycTanycN and cMRF+ anycTanycN and lateral lymph nodes on MRI

Disqualifiers

No informed consent received for participation.

Patients with rectal cancer that is scheduled for (chemo) radiotherapy but is not palpable during rectal examination (10-15 cm) as this cannot be examined by digital examination and followed as scheduled.

Contraindication for MRI such as presence of non compatible metallic implants or claustrophobia.

Trial design

Treatments tested in this trial

  • endoscopy
  • Surgery
  • MRI

Treatment groups

400 Participants
are divided into 2 treatment groups

Sponsors and collaborators

Sahlgrenska University Hospital

Lead sponsor

Karolinska Institutet

Collaborator