Acute Treatment of Migraine

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Review clinical trials related to Acute Treatment of Migraine. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

A Study to Learn About the Safety of Taking an Additional Dose of the Medicine Rimegepant in Adults With Migraine

Acute treatments for migraine may not provide sufficient pain relief after an initial dose, and a second dose of a given medication may be needed to fully abort an attack. International Headache Society (IHS) global practice recommendations for the Acute Treatment of Migraine suggest a second dose of the same medication within the recommended dose limit in people with headache relapse after successful initial treatment of a migraine attack. The primary purpose of this study is to evaluate the safety and tolerability of redosing of rimegepant when taken for the acute treatment of a migraine attack, as it is possible that some patients may benefit from a second dose of rimegepant in this setting.

Participants needed: 400
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: PfizerUpdated: Jul 1, 2026Locations: 6
Eligibility criteria

Eligible participants include adult participants aged 18 years of age or older w... [+2]

Status: Recruiting

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

The purpose of this study is to test the long-term safety of rimegepant in the acute treatment of migraine in children and adolescents (≥ 6 to \< 18 years of age).

Participants needed: 600
Trial details
Phase: Phase 3Age: 6-17Biological sex: AllType: InterventionalSponsor: PfizerUpdated: Jul 1, 2026Locations: 126
Eligibility criteria

History of migraine (with or without aura) for ≥ 6 months before Screening. [+7]

History of cluster headache or hemiplegic migraine headache. [+6]

Status: Recruiting

A Study to Learn About the Study Medicine Called Zavegepant (PF-07930207) in Children With a History of Migraine

The purpose of the study is to learn about safety and how the body processes the study medicine called Zavegepant (PF-07930207) in children with a history of migraine. This study helps understand how the medicine is changed and removed from the body after taking it. This study is seeking participants who: * Are children aged between 6 and less than 12 years old * Have had migraine for at least 6 months. * Weigh more than 15 kilograms All participants in this study will receive zavegepant as a nasal spray once (one spray into one nostril). The dose of the study medicine that each participant receives will depend on how much the participant weighs. The study will look at the experiences of the participants receiving the study medicine and collect data to better understand the possible benefits and unwanted effects of different doses of the study medicine. Participants will take part in this study for up to 10 weeks. During this time, they will have 3 study visits at the study clinic, and 2 follow-up phone calls.

Participants needed: 16
Trial details
Phase: Phase 1Age: 6-11Biological sex: AllType: InterventionalSponsor: PfizerUpdated: Mar 18, 2026Locations: 13
Eligibility criteria

Participants aged 6 years to less than 12 years. [+2]

Evidence or history of clinically significant disease. [+7]