Health Trials

Advanced or Metastatic Melanoma

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Review clinical trials related to Advanced or Metastatic Melanoma. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Belvarafenib in Combination With Cobimetinib in Patients With Locally Advanced or Metastatic NRAS-Mutant Melanoma

This is a Phase 2 open-label, multicenter, single-arm study evaluating the combination of Belvarafenib and Cobimetinib in patients with locally advanced or metastatic melanoma with NRAS mutations. The study plans to assess ORR, DCR, DOR, TTP, PFS, OS and safety of the participating subjects. Treatment cycles for all subjects will be 28 days in duration and Belvarafenib and Cobimetinib will be administered orally in combination.

Participants needed: 45
Trial details
Phase: Phase 2Age: 19+Biological sex: AllType: InterventionalSponsor: Hanmi Pharmaceutical Company LimitedUpdated: Mar 4, 2026Locations: 10
Eligibility criteria

Have histologically, cytologically confirmed locally advanced or metastatic mela... [+5]

Have a history of prior treatment with RAF, MEK, or ERK inhibitor. [+3]

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