Health Trials

Advanced Systemic Mastocytosis (AdvSM)

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Review clinical trials related to Advanced Systemic Mastocytosis (AdvSM). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

(Apex) Bezuclastinib in Patients With Advanced Systemic Mastocytosis

This is an open-label, two-part Phase 2 study investigating CGT9486 for the treatment of patients with Advanced Systemic Mastocytosis (AdvSM), including patients with Aggressive SM (ASM), SM with Associated Hematologic Neoplasm (SM-AHN), and Mast Cell Leukemia (MCL).

Participants needed: 140
Trial details
Phase: Phase 2Age: 18+Biological sex: AllType: InterventionalSponsor: Cogent Biosciences, Inc.Updated: May 5, 2026Locations: 42
Eligibility criteria

Diagnosed with one of the following advanced mastocytosis diagnoses by Eligibili... [+6]

Persistent toxicity from previous therapy for AdvSM that has not resolved to ≤ G... [+27]

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