Ankle Arthritis

4

Review clinical trials related to Ankle Arthritis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Outcomes of Surgical Treatment Using a Custom-made Device for Total Ankle and Talar Replacement in the Management of Severe Cases of Bone Loss or Bone Compromise: a Pilot Study.

On February 17th, 2021, the FDA officially approved the use of the first patient-specific 3D-printed talar implant for compassionate use. This is a patient-specific talar spacer designed to completely replace the talus for the treatment of talar avascular necrosis. The implant represents an alternative to other surgical procedures that allows joint preservation. Recently, at the First Clinic of the Rizzoli Orthopaedic Institute, a prosthetic device has been developed that combines the tibial and meniscal components of a FAR-type ankle prosthesis (Adler Ortho) with a total talus replacement implant. Since the device is patient-specific and implanted using custom-made cutting guides, it reduces surgical invasiveness on surrounding bone structures as well as on ligamentous and tendinous structures, thereby preserving ankle function as much as possible. The customization is based on a next-generation prosthetic model produced using additive manufacturing technology and featuring hypoallergenic properties, as it is made of a titanium alloy and treated with a nitriding process. The aim of this study is therefore to evaluate the outcomes of this prosthetic device over time.

Participants needed: 26
Trial details
Age: 35-75Biological sex: AllType: ObservationalSponsor: Istituto Ortopedico RizzoliUpdated: May 6, 2026Locations: 1Duration: 36 Months
Eligibility criteria

Male or female patients aged between 35 and 75 years. [+5]

Patients unable to understand or provide informed consent. [+11]

Status: Not yet recruiting

Incidence of Subtalar Joint Fusion After Isolated Ankle Fusion

It is important to know a truer incidence of the need for subtalar and midfoot fusions, following an isolated ankle fusion, in order to better inform our patients of the likelihood of needing further surgery in the future. It is also important to understand whether pre-existing radiological arthrosis is likely to lead to the need for a fusion in the future and also how important the alignment of the ankle joint, after a fusion, may influence that. The aim of the study is to review the patients' notes and radiology who have had a previous isolated ankle fusion and then to see whether they subsequently required further surgery.

Participants needed: 400
Trial details
Age: 18-100Biological sex: AllType: ObservationalSponsor: Robert Jones and Agnes Hunt Orthopaedic and District NHS TrustUpdated: Apr 8, 2025
Eligibility criteria

Not listed

Status: Recruiting

Intraosseous vs. Intravenous Vancomycin Administration in Total Ankle Arthroplasty

The purpose of this study is to compare two different antibiotic regimens and techniques during total ankle arthroplasty (TAA). Primary Objective: Comparable levels of vancomycin will be found in bone, soft tissue, and systemic samples between patient groups. Secondary Objective: Compare 30 day and 90 day post-operative complication rates (infection) between the control (standard IV administration of vancomycin) vs the interventional group (intraosseous administration of vancomycin). The investigators hypothesize that there will be no difference in complication (infection) rates between groups.

Participants needed: 40
Trial details
Phase: Phase 4Age: 18+Biological sex: AllType: InterventionalSponsor: The Methodist Hospital Research InstituteUpdated: Jan 24, 2025Locations: 1
Eligibility criteria

Patient is undergoing total ankle arthroplasty. [+2]

Previous lower extremity surgery that in the opinion of the principal investigat... [+7]

Status: Recruiting

Total Ankle Replacement: Clinical and Radiological Outcomes

This retrospective and prospective study intends to evaluate the epidemiology and effectiveness of ankle joint surgery in patients operated from January 2011 to March 2026, evaluating the results both clinically and radiographically.

Participants needed: 1,066
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: I.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioUpdated: Aug 28, 2018Locations: 1
Eligibility criteria

Males and females [+2]