Health Trials

Antimicrobial Resistance (AMR)

4

Review clinical trials related to Antimicrobial Resistance (AMR). Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

PK/PD Relationship of CAZ/AVI and FOS in the Treatment of Patients With Infections Due to CRE

A multicenter international prospective observational pharmacological study in adult patients (≥18 years) treated with ceftazidime/avibactam (CAZ/AVI) alone or with CAZ/AVI plus fosfomycin (FOS) for infection due to carbapenem-resistant Enterobacterales (CRE) (KPC and/or OXA-48).

Participants needed: 60
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: IRCCS Azienda Ospedaliero-Universitaria di BolognaUpdated: Jun 12, 2026Locations: 2
Eligibility criteria

Signature of the informed consent [+2]

Polymicrobial/mixed infections with exception of cases with multiple Enterobacte...

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Status: Not yet recruiting

Development and Implementation of Mobile Antibiograms to Optimize Empirical Antibiotic Prescriptions Among Prescribers in Tertiary Hospitals in Tanzania

Antimicrobial resistance (AMR) is a critical issue, especially in Africa, with resistance to common antibiotics reaching 100% in some areas. In Tanzania, limited access to culture tests and antibiograms forces healthcare providers to rely on experience for prescribing, heightening AMR risks. This study aims to determine the effectiveness of mobile antibiograms in optimizing empirical antibiotic therapy in tertiary hospitals in Tanzania.

Participants needed: 300
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: Muhimbili University of Health and Allied SciencesUpdated: Feb 6, 2026Locations: 2
Eligibility criteria

All prescribers working in the selected tertiary referral hospitals [+2]

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Status: Recruiting

NCCR AntiResist:: New Approaches to Combat Antibiotic-resistant Bacteria

This is an explorative, mono-center study including prospectively collected patient samples from the University Hospital of Basel. It is to investigate antimicrobial resistance (AMR) including three clinical manifestations of infectious diseases: urinary tract infection, pneumonia and deep-seated infections. The focus is on four bacteria (E. coli, Klebsiella species, S. aureus, P. aeruginosa) that are part of the high priority list of World Health Organization (WHO). Residual patient samples are analysed for proteomic, metabolomic and transcriptomic analysis, immunocytochemical or fluorescence in-situ hybridisation (FISH) analysis, flow cytometry analysis (FACS) and immunophenotyping and exploration of bacterial properties.

Participants needed: 8,000
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: University Hospital, Basel, SwitzerlandUpdated: Mar 4, 2025Locations: 1
Eligibility criteria

E. coli [+8]

Patients who have refused research and reuse of their data/samples (e.g. general... [+3]

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Status: Recruiting

PK/PD Analysis of Ceftazidime/Avibactam or Cefiderocol With or Without Fosfomycin for the Treatment of Difficult To-treat Gram-negative Infections

A multicenter, national, prospective, observational pharmacological study of patients with difficult-to-treat Gram-negative infections treated with ceftazidime/avibactam (CAZ/AVI) or cefiderocol (CEF) monotherapy or combination therapy with ceftazidime/avibactam associated with fosfomycin (FOS) or cefiderocol associated with fosfomycin.

Participants needed: 120
Trial details
Biological sex: AllType: ObservationalSponsor: University of BolognaUpdated: Oct 21, 2024Locations: 11
Eligibility criteria

Patients with infection due to a difficult-to-treat Gram-negative bacteria treat... [+1]

Premature newborns [+4]

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