Health Trials

Aortic Stenosis, Calcific

2

Review clinical trials related to Aortic Stenosis, Calcific. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

PCSK9 Inhibitors in the Treatment of Calcific Aortic Stenosis

Calcific aortic stenosis (CAS) can cause severe adverse cardiac events, but there are currently no effective drugs that can prevent or delay the progression of the disease. Our trial aims to investigate the effect of PCSK9 inhibitors on preventing or delaying the progression of CAS.

Participants needed: 160
Trial details
Phase: Phase 3Age: 18-85Biological sex: AllType: InterventionalSponsor: Beijing Anzhen HospitalUpdated: Apr 2, 2026Locations: 1
Eligibility criteria

Aged 18-85 years old, clinically diagnosed with mild or moderate CAVS (echocardi... [+3]

Any previous treatment with PCSK9 inhibitors; [+22]

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Status: Recruiting

PROGRESS: Management of Moderate Aortic Stenosis by Clinical Surveillance or TAVR

This study objective is to establish the safety and effectiveness of the Edwards SAPIEN 3 / SAPIEN 3 Ultra / SAPIEN 3 Ultra RESILIA Transcatheter Heart Valve systems in subjects with moderate, calcific aortic stenosis. Following completion of enrollment, subjects will be eligible for enrollment in the continued access phase of the trial.

Participants needed: 2,250
Trial details
Age: 65+Biological sex: AllType: InterventionalSponsor: Edwards LifesciencesUpdated: Dec 17, 2025Locations: 80
Eligibility criteria

65 years of age or older at time of randomization [+3]

Native aortic annulus size unsuitable for the THV [+10]

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