Asymptomatic Apical Periodontitis

3

Review clinical trials related to Asymptomatic Apical Periodontitis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Evaluation of Postoperative Pain and Success Rate Between Lateral Condensation and Warm Vertical Obturation Techniques

Brief Summary Postoperative pain is a common complication following root canal treatment, particularly in necrotic teeth with asymptomatic apical periodontitis. Although obturation technique has been suggested as a contributing factor to postoperative discomfort, direct clinical comparisons between commonly used methods remain limited. Cold lateral condensation has traditionally been considered the standard obturation technique, while warm vertical obturation systems such as Obtura II have gained popularity due to their potential for improved adaptation of gutta-percha. This randomized controlled clinical trial aims to compare postoperative pain experience and treatment outcomes following cold lateral condensation and warm vertical obturation in single-rooted necrotic teeth. Postoperative pain will be assessed during the early healing period, along with patient-reported outcomes and short-term clinical and radiographic healing. The results of this study are expected to provide clinically relevant evidence to support evidence-based obturation technique selection and improve patient comfort in endodontic practice.

Participants needed: 80
Trial details
Age: 18+Biological sex: AllType: InterventionalSponsor: University of JordanUpdated: Apr 2, 2026Locations: 1
Eligibility criteria

Adults aged 18 years or older. [+3]

Teeth diagnosed with symptomatic apical periodontitis. [+5]

Status: Recruiting

Effect of Calcium-Based Bioceramic Sealer and Resin-Based Sealer on Postoperative Pain

This study aims to compare the effect of calcium-based bioceramic sealer and resin-based sealer on postoperative pain in adult patients with asymptomatic apical periodontitis undergoing root canal treatment. Asymptomatic apical periodontitis is a condition where the tissue around the tip of the tooth root is inflamed or shows a lesion on X-ray, but the patient does not experience pain. A total of 60 patients will be randomly assigned to receive root canal treatment with either the bioceramic sealer (Group A) or the resin-based sealer (Group B). Pain after treatment will be measured using a 0-10 Numeric Pain Rating Scale at 4, 24, and 48 hours post-treatment. The highest pain score reported will determine whether the treatment is considered a success (no or mild/moderate pain) or failure (severe pain). The results of this study will provide evidence on which sealer is associated with less postoperative pain, helping clinicians make informed decisions about root canal filling materials.

Participants needed: 60
Trial details
Age: 18-55Biological sex: AllType: InterventionalSponsor: Fatima Memorial HospitalUpdated: Dec 24, 2025Locations: 1
Eligibility criteria

Both genders. [+5]

Medically compromised patients (e.g., those with immunosuppressive or systemic d... [+5]

Status: Recruiting

Comparison of the Effects of Bio Ceramic and Epoxy Resin-based Sealers on Postoperative Pain After Root Canal Treatment

This study aims to compare the effect of bio ceramic sealer and resin-based sealer on the intensity and occurrence of post operative pain in single rooted teeth with asymptomatic apical periodontitis.

Participants needed: 40
Trial details
Age: 18-60Biological sex: AllType: InterventionalSponsor: Primary Health Care Corporation, QatarUpdated: Nov 25, 2024Locations: 1
Eligibility criteria

Permanent single rooted tooth 1-1 configuration and complete root development. [+3]

Medically compromised patients. [+5]