Status: Recruiting
Potential Role of Sirtuins As Epigenetic Biomarkers of the Patient with Atherosclerosis or Calcific Aortic Stenosis
The project aims to shed light on the role of Sirtuins, enzymes belonging to the third class of histone deacetylases (class III) involved in epigenetic modifications (deacetylation), focusing mainly on Sirtuin 6 (SIRT6), as a regulator of atherosclerosis and severe aortic valve stenosis through molecular-based and epigenetic studies in human VSMC cells.
Participants needed: 3
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: IRCCS SYNLAB SDNUpdated: Mar 11, 2025Locations: 1
Eligibility criteria
Patients with atherosclerosis or calcific aortic stenosis with and without diabe... [+2]
Patients for whom biological material cannot be recovered for study purposes; [+1]