Health Trials

ATTR Amyloidosis With Cardiomyopathy

2

Review clinical trials related to ATTR Amyloidosis With Cardiomyopathy. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Prospective Evaluation of Artificial Intelligence-enabled Screening for Transthyretin Amyloid Cardiomyopathy (ATTR-CM)

The TRACE-AI Diagnostic Study will evaluate the performance of artificial intelligence (AI) models applied to electrocardiograms (AI-ECG) and echocardiograms (AI-Echo) to identify transthyretin amyloid cardiomyopathy (ATTR-CM) in adults with heart failure. Model performance will be validated through comparison with technetium-99m pyrophosphate (PYP) imaging results.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Yale UniversityUpdated: Feb 10, 2026Locations: 1
Eligibility criteria

Patients 18 years or older with at least one of each component cardiovascular di... [+2]

Patients who have opted out of research studies [+5]

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Status: Recruiting

A Multicenter Study on Atrioventricular Regurgitation in Transthyretin Amyloid Cardiomyopathy: Definition, Prevalence, and Prognostic Impact.

The objective of this prospective registry study is to comprehensively characterize the prevalence, (semi-) quantitative parameters, and associated clinical outcomes of mitral (MR) and tricuspid regurgitation (TR) in patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM). The study further aims to develop and implement new grading standards for the quantitative assessment of regurgitation severity, tailored to the distinct hemodynamic profile of ATTR-CM. This approach seeks to address the limitations of current regurgitation severity classifications, which do not adequately reflect the unique pathophysiology of a restrictive phenotype as seen in ATTR-CM.

Participants needed: 600
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: Medical University of ViennaUpdated: Feb 19, 2025Locations: 8
Eligibility criteria

Diagnosis of ATTR-CM according to current diagnostic criteria [+3]

Severe aortic valve disease requiring intervention [+1]

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