Bladder Cancer Cell Transitional

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Condition / disease
Location
Status: Not yet recruiting

Sarcopenia and NMIBC Prognosis Study

The goal of this observational study is to evaluate whether body composition abnormalities (sarcopenia, myosteatosis, and obesity) and nutritional status influence the risk of recurrence and progression in adult patients with non-muscle-invasive bladder cancer (NMIBC). The main questions it aims to answer are: Do sarcopenia, myosteatosis, obesity, or malnutrition increase the likelihood of NMIBC recurrence and progression? Can clinical, laboratory, and CT-derived body composition parameters serve as predictive biomarkers that improve individualized risk stratification? Participants will undergo routine clinical and radiologic assessments, including: * completion of the SARC-F and NRS nutritional screening questionnaires * anthropometric measurements (BMI, waist circumference) * laboratory evaluation including serum albumin and testosterone * CT-based assessment of skeletal muscle index (SMI) and muscle density (SMD) * standard TURBT and structured follow-up with cystoscopy, cytology, imaging, and clinical evaluations to document recurrence and progression.

Participants needed: 150
Trial details
Age: 18+Biological sex: AllType: ObservationalSponsor: General Hospital Sveti DuhUpdated: Dec 16, 2025
Eligibility criteria

Adults aged 18 years or older [+5]

Low-risk NMIBC, as defined by clinical guidelines [+6]