Status: Recruiting
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
This study will test an investigational drug called AZD1390 in combination with radiation therapy for the treatment of brain tumors. This is the first time AZD1390 is being given to patients. This study will test safety, tolerability and PK (how the drug is absorbed, distributed and eliminated) of ascending doses of AZD1390 in combination with distinct regimens of radiation therapy
Participants needed: 180
Trial details
Phase: Phase 1Age: 18-130Biological sex: AllType: InterventionalSponsor: AstraZenecaUpdated: Dec 22, 2025Locations: 12
Eligibility criteria
Provision of formalin-fixed paraffin embedded tissue sample from primary or meta... [+20]
Administration of chemotherapy or any investigational drug in the 28 days or car... [+15]