Chronic Ankle Instability, CAI

11

Review clinical trials related to Chronic Ankle Instability, CAI. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Recruiting

Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability

Effects of Cervical and Oculomotor Exercises on Functional Status, Balance, and Proprioception in Chronic Ankle Instability

Participants needed: 38
Trial details
Age: 18-45Biological sex: AllType: InterventionalSponsor: Izmir Katip Celebi UniversityUpdated: Jun 8, 2026Locations: 1
Eligibility criteria

Diagnosed with unilateral chronic ankle instability (CAI) in accordance with the... [+3]

History of surgery or fracture in the lower extremities or spine [+7]

Status: Recruiting

Ankle vs. Hip vs. Combined Strengthening in Chronic Ankle Instability

Chronic ankle instability (CAI) is a common condition that can develop after a lateral ankle sprain. Up to 40% of people who sprain their ankle experience a recurrence within a year, and as many as 30% develop persistent symptoms such as ankle "giving way," weakness, or instability. These symptoms can limit daily activities, sports participation, and increase the risk of future sprains. Muscle weakness in both the ankle and hip has been identified as an important factor contributing to CAI. Strengthening these muscles may therefore help improve stability and function. The SHAC study is a randomized controlled trial designed to compare three different strengthening programs in people with chronic ankle instability: (1) an ankle-focused strengthening program, (2) a hip-focused strengthening program, and (3) a combined ankle-hip strengthening program. The goal is to determine which approach leads to the greatest improvement in functional ability, muscle strength, balance, and ankle mobility. A total of 45 participants aged 18 to 35 years with documented chronic ankle instability will be recruited from local sports clubs and the University of Liège. All participants must have a history of at least one ankle sprain that occurred more than 12 months before entering the study, report episodes of ankle instability in the previous six months, and meet specific questionnaire criteria (CAIT \< 24 and FAAM Sport \< 80%). People with recent injuries, previous lower-limb surgery, fractures requiring realignment, neuromuscular conditions, or current pain or swelling will not be able to participate. After the first assessment (T1), participants will be randomly assigned to one of the three groups. Each intervention lasts four weeks and includes three supervised sessions per week. All strengthening exercises are isometric, performed using a handheld dynamometer to measure force accurately. The ankle program includes plantarflexion, dorsiflexion, inversion, and eversion exercises. The hip program includes clamshells, hip external rotation, abduction, and extension. The combined group alternates between hip and ankle exercises. A warm-up and standardized familiarization are performed before each session. All participants will attend two additional assessment sessions: one immediately after the four-week program (T2) and one at a later follow-up time point (T3). During each visit, they will complete functional questionnaires, report their sports participation, and undergo several strength and performance tests. These include hip and ankle muscle strength measurements using a dynamometer, the Heel Rise Test, the modified Y-Balance Test, the Side Hop Test, and a dorsiflexion mobility test. The study aims to identify whether one of the strengthening approaches leads to better functional outcomes for individuals with chronic ankle instability. Understanding these effects may help clinicians design more effective rehabilitation programs for people recovering from ankle sprains and for those experiencing ongoing instability. Participant data will be kept confidential and stored securely in anonymized form for 20 years. Participation is voluntary, and individuals may withdraw at any time without consequences. Results will be presented anonymously in scientific publications and conferences.

Participants needed: 45
Trial details
Age: 18-35Biological sex: AllType: InterventionalSponsor: University of LiegeUpdated: May 26, 2026Locations: 1
Eligibility criteria

Have a history of at least one major ankle sprain that occurred at least 12 mont... [+5]

Have had a recent injury of less than three months prior to enrolment in the stu... [+4]

Status: Not yet recruiting

Lower Extremity Mobility for CAI

This study will be conducted to determine the effect of addition of ankle mobility versus hip mobility exercises to traditional rehabilitation to patients with chronic ankle instability. the main purpose is to answer the following question: * out of these interventions which would better improve lower limb flexibility, range of motion, severity of functional instability and dynamic postural control? Researcher will compare between ankle mobility versus hip mobility exercises Participants will be allocated in 2 experimental groups: * group A will include 20 patients receiving conventional physiotherapy in addition to ankle mobility exercises * group B will include 20 patients receiving conventional physiotherapy in addition to hip mobility exercises Patients will receive 3 sessions per week for 6 weeks in a physiotherapy outpatient facility for both groups

Participants needed: 40
Trial details
Age: 18-30Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: May 18, 2026
Eligibility criteria

Adults (18-30 years old) with chronic ankle instability [+5]

Other lower extremity injury surgery 6 months before testing [+3]

Status: Recruiting

Effects of Ankle Evertor Fatigue on Force Sense and Neuromuscular Activation in Subjects With Chronic Ankle Instability

The goal of this observational study is to investigate whether ankle evertor muscle fatigue impairs force perception and alters neuromuscular activation patterns during submaximal isometric contractions, and whether these effects differ between individuals with chronic ankle instability (CAI) and individuals without CAI.

Participants needed: 50
Trial details
Age: 18-45Biological sex: AllType: ObservationalSponsor: University of LjubljanaUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

Age between 18 and 45 years, [+8]

Status: Recruiting

Effects of Ankle Evertor Fatigue on Perturbed Gait

This study will investigate the effects of ankle evertor muscle fatigue on gait stability during treadmill walking with mechanical perturbations. Participants will walk at two speeds (0.4 m/s and 1.0 m/s) while random medial and lateral perturbations (\<10% body weight) are applied to the pelvis. Surface EMG from ankle muscles and center of pressure (COP)-based gait parameters (e.g., step length, step width, single support duration, COP trajectory) will be analyzed before and immediately after an isotonic fatigue protocol of the ankle evertors.

Participants needed: 40
Trial details
Age: 18-45Biological sex: AllType: ObservationalSponsor: University of LjubljanaUpdated: Apr 29, 2026Locations: 1
Eligibility criteria

Age between 18 and 45 years, [+8]

Other pathologies of the ankle joint. [+1]

Status: Not yet recruiting

The Effect of Cognitive Dual-Task on Athletic Performance Parameters in Volleyball Players With and Without Chronic Ankle Instability

The aim of this study is to investigate the effect of the cognitive dual-task on athletic performance parameters in volleyball players with and without chronic ankle instability. In addition, it will examine how a pathology in the lower extremity affects upper extremity function.

Participants needed: 60
Trial details
Age: 18-25Biological sex: AllType: ObservationalSponsor: Hacettepe UniversityUpdated: Feb 27, 2026Locations: 1
Eligibility criteria

Chronic Ankle Instability Group Patients who meet all of the following criteria... [+15]

Presence of rheumatic, neurological, or cardiovascular disease, [+3]

Status: Not yet recruiting

Effects of Pilates Training on Ankle Proprioception, Postural Control and Performance in Footballers With Chronic Ankle Instability

This study aims to contribute to the effects of Pilates training on ankle proprioception, postural control, and performance in football players with chronic ankle instability. Eighty eight participants will be randomly allocated into two groups and will receive both Pilates and balance training for eight weeks. it is hypothesized that the group that will receive Pilates taring will produce greater improvements as compared to other group.

Participants needed: 88
Trial details
Age: 22-35Biological sex: MaleType: InterventionalSponsor: Lahore University of Biological and Applied SciencesUpdated: Dec 5, 2025
Eligibility criteria

History of unilateral ankle sprain in past 12 months [+3]

Bilateral ankle sprains [+2]

Status: Not yet recruiting

Validation of a Portable Ankle Arthrometer

The purpose of this study is to assess the validity and reliability of a prototype portable ankle arthrometer in various populations. There are two aims to this study. Aim 1 will look to determine the reliability and validity of a prototype portable ankle arthrometer on young adults with no history of ankle sprain, copers, and young adults with chronic ankle instability. It is hypothesized that the prototype portable ankle arthrometer will be a valid and reliable tool to assess joint laxity across the three different populations. Aim 2 will look to determine the validity of a prototype portable ankle arthrometer in young adults with an acute ankle sprain across multiple timepoints in their first month post injury. It is hypothesized that the prototype portable ankle arthrometer will be a valid tool to assess joint laxity at three different timepoints for the same individual.

Participants needed: 62
Trial details
Age: 18-40Biological sex: AllType: ObservationalSponsor: University of VirginiaUpdated: Sep 9, 2025Locations: 1
Eligibility criteria

Young adults between the ages of 18 and 40. [+7]

Previous history of ankle fracture. [+3]

Status: Not yet recruiting

Extracorporeal Shock Wave Versus Photobiomodulation Therapy for Chronic Ankle Instability

PURPOSE: To Compare between the effect of extra corporeal shock wave and Photobiomodulation on pain level, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability. BACKGROUND: Lateral ankle sprains are the most common lower limb musculoskeletal injury incurred by individuals who participate in sports and recreational physical activities Approximately 40% of individuals who sustain a LAS develop a condition known as chronic ankle instability (CAI) (Miklovic et al., 2018), The lateral ligamentous complex is the main structure affected in 80-85% of these injuries, which are originated from a sudden inversion or supination trauma (Mansur et al., 2021). The ligament system plays a fundamental role in the ankle's stability and includes a talocrural complex and a subtalar complex that are functionally related. For the talocrural joint, three lateral collateral ligaments are present and one medial collateral ligament (Bonnel et al., 2010). Physical examination is mostly the first diagnostic step in the assessment of ankle injuries. Imaging modalities such as ultrasonography (US) and magnetic resonance imaging (MRI) play a major role in providing a detailed depiction of ankle tendons and ligaments (Hosseinian et al., 2022). The effect of ESWT is Higher multiplication of collagen fibers; faster organization of muscle fibers and vascularization by treatment with radial shockwaves (Schnurrer-Luke-Vrbanic et al., 2018), ESWT could improve pain, ankle instability, ankle function, dorsiflexion ROM, and dynamic balance in patients with CAI (Le et al., 2022). Photobiomodulation Therapy (PBMT) is effective for patients with an ankle sprain. PBMT showed high effect size with a moderate level of evidence on pain intensity and is related to the PBMT intensity and frequency (Alayat et al., 2024). HYPOTHESES: There is no statistically significant effect of extra corporeal shock wave versus photobiomodulation on level of pain, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability. RESEARCH QUESTION: Is there any effect of extra corporeal shock wave versus Photobiomodulation on pain level, ROM, muscle strength, function level, dynamic balance and thickness of ligament in patients with chronic ankle instability?

Participants needed: 38
Trial details
Age: 20-65Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Aug 24, 2025Locations: 1
Eligibility criteria

they had any medical condition that could cause ankle pain (arthritis, fracture,...

Status: Not yet recruiting

MOTOR TRAINING VERSUS MOTOR COGNITIVE TRAINING IN ATHLETES WITH CHRONIC ANKLE INSTABILITY

This study aims to evaluate the effect of one-leg balance activity (OLBA) combined with visual feedback using BlazePod™ as a dual motor-cognitive rehabilitation task in basketball players with Chronic Ankle Instability (CAI). The intervention will be compared to OLBA alone as a motor task. Outcomes measured include dynamic balance, sense of instability, response time, athletic performance, and self-reported physical function. This study will help improve rehabilitation strategies for athletes suffering from ankle instability.

Participants needed: 60
Trial details
Age: 18-30Biological sex: AllType: InterventionalSponsor: Cairo UniversityUpdated: Jul 22, 2025Locations: 1
Eligibility criteria

Young adult basketball athletes aged between (18 - 30) years. [+5]

A history of previous surgery or fracture to musculoskeletal structure (bone, jo... [+5]

Status: Not yet recruiting

Radiological and Clinical Measures as Predictors of Dynamic Postural Control Deficits in Chronic Ankle Instability

The purpose of this study is to investigate the association between dynamic postural control and clinical measures of (ankle and hip strength, ankle DFROM and position sense) and radiological measures in patients with unilateral CAI.

Participants needed: 50
Trial details
Age: 18-30Biological sex: AllType: ObservationalSponsor: Cairo UniversityUpdated: Jul 3, 2025
Eligibility criteria

At least one significant unilateral lateral ankle sprain in which the subject wa... [+5]

A previous trauma or surgery to the trunk or lower extremities other than an ank... [+4]