Chronic Knee Osteoarthritis

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Review clinical trials related to Chronic Knee Osteoarthritis. Use filters to narrow results by trial status, phase, treatment, biological sex and sponsor.

Condition / disease
Location
Status: Not yet recruiting

Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis

The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; \>50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is: Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.

Participants needed: 52
Trial details
Age: 50+Biological sex: AllType: InterventionalSponsor: Aga Khan UniversityUpdated: Mar 27, 2026
Eligibility criteria

Both gender patients of age more than 50 years. [+3]

Lack of consent [+6]

Status: Recruiting

Shock Wave Versus Traditional Physical Therapy for Adult Chronic Knee Osteoarthritis

This study aims to compare the effectiveness of extracorporeal shock wave therapy (ESWT) versus structured therapeutic exercise in patients with chronic knee osteoarthritis (KOA), with respect to pain reduction and improvement of knee function.

Participants needed: 40
Trial details
Age: 40+Biological sex: AllType: InterventionalSponsor: German International UniversityUpdated: Mar 19, 2026Locations: 1
Eligibility criteria

Adults ≥ 40 years with clinical and radiographic diagnosis of chronic knee osteo... [+3]

Prior knee surgery within last 6 months. [+2]

Status: Not yet recruiting

Treating Chronic Pain of Peripheral Nerve Origin With the Novel Noninvasive Hypersound Neuromodulation System

First, the subject will undergo screening and provide informed consent. Baseline measurements are then taken. The subject remains seated with back support throughout the session. The technician verifies and marks the knee for treatment and wraps an antenna applicator strap around the lower leg near the knee. The device is turned on in test mode to confirm the therapy location, with the subject identifying when they feel a sensation over their pain area. The power threshold for this sensation is recorded. The therapy, which lasts 15 minutes, is delivered at 90% of this threshold to ensure the subject does not feel it. After therapy, post-treatment measurements are taken.

Participants needed: 5
Trial details
Phase: Early Phase 1Age: 18-75Biological sex: AllType: InterventionalSponsor: Hypersound Medical IncUpdated: Feb 23, 2026
Eligibility criteria

Pain greater than mid-range using standardized pain inventory (SPI). [+3]

Existing Peripheral Nerve Stimulator Implant in the lower extremities